- The Director, gangs, CCTV cameras and death row dodger, James Earl Cash, from the first Manhunt won't play a part.
- Manhunt 2 's main character, scientist Dr Daniel Lamb, is locked in a private asylum by The Project - shady backers of a top secret drugs-based weapons program that Lamb was working on.
- After breaking out of the asylum, Daniel Lamb goes on the run with psychotic inmate Leo Kasper, who is happy to coach Lamb on the brutal art of violence.
- Like the first Manhunt, kills are executed in three deadly shades - Hasty, Violent and Gruesome.
- Environmental kills have been introduced (push an enemy face first into a live fuse box, for example)
- Loud ambient noises can be exploited by Lamb to drown out his own crashing about.
- When hiding in shadows, if an enemy comes close the player will sometimes have to copy a button combo in order to regulate Lamb's breathing and ensure that he remains undetected.
- Lamb can climb and crawl - two moves that Manhunt's James Earl Cash couldn't do.
- Guns can be used for stealth kills.
But wait, there's more; "Later in the game, a member of The Project has both his plums and a pair of vertebrae removed with a pair of pliers."
Ouuuuuuuuuuuch!!!
It's a awesome game, but it sucks they cut out the part with the plums and his vertebrae removed with the pliers.... just to make the "mature rating" and also the Executions are censored unless you have a codebreaker, gameshark, or action replay... (I have a codebreaker) but over all it's an awesome game and is very addicitng to play 
